Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

Injuries to the spinal cord result in permanent disabilities that limit daily life activities. The
main reasons for these poor outcomes are the limited regenerative capacity of central …

Spinal cord injury (SCI) is characterized by a complex and prolonged injury process that
exacerbates the damage induced by the primary injury and inhibits the potential for …

Traumatic spinal cord injury (SCI) is a devastating event for which functional recovery
remains elusive. Due to the complex nature of SCI pathology, a combination treatment …

Spinal cord injury (SCI) results in permanent loss of function leading to often devastating
personal, economic and social problems. A contributing factor to the permanence of SCI is …