Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Omics-based biomarkers discovery for Alzheimer's disease
Q Aerqin, ZT Wang, KM Wu, XY He, Q Dong… - Cellular and Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …
Plasma proteomic profiles predict individual future health risk
Developing a single-domain assay to identify individuals at high risk of future events is a
priority for multi-disease and mortality prevention. By training a neural network, we …
priority for multi-disease and mortality prevention. By training a neural network, we …
Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer's disease
A deeper understanding of the molecular processes underlying late-onset Alzheimer's
disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput …
disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput …
Mediating and moderating effects of plasma proteomic biomarkers on the association between poor oral health problems and brain white matter microstructural …
The plasma proteome can mediate associations between periodontal disease (Pd) and
brain white matter integrity (WMI). We screened 5089 UK Biobank participants aged 40–70 …
brain white matter integrity (WMI). We screened 5089 UK Biobank participants aged 40–70 …
Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases
Immune system and blood–brain barrier dysfunction are implicated in the development of
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Alzheimer's and other dementia-causing diseases, but their causal role remains unknown …
Impact of hypertension prevalence trend on mortality and burdens of dementia and disability in England and Wales to 2060: a simulation modelling study
Background Previous estimates of the impact of public health interventions targeting
hypertension usually focus on one health outcome. This study aims to consider the effects of …
hypertension usually focus on one health outcome. This study aims to consider the effects of …
Perspectives of ozone induced neuropathology and memory decline in Alzheimer's disease: A systematic review of preclinical evidences
This systematic review aims to discover the plausible mechanism of Ozone in AD, to boost
translational research. The main focus of our review lies in understanding the effects of …
translational research. The main focus of our review lies in understanding the effects of …
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers
and molecular process of cognitive impairment. Few studies have investigated the …
and molecular process of cognitive impairment. Few studies have investigated the …