Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Cancers arise through the accumulation of genetic and epigenetic alterations that enable
cells to evade telomere-based proliferative barriers and achieve immortality. One such …

The innate immune response is a rapid response to pathogens or danger signals. It is
precisely activated not only to efficiently eliminate pathogens but also to avoid excessive …

Innate immunity provides the initial defence against infection and it is now clear that long
non-coding RNAs (lncRNAs) are important regulators of this response. Following activation …

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of gene expression,
yet their contribution to immune regulation in humans remains poorly understood. Here, we …

Induction of interferons during viral infection is mediated by cellular proteins that recognise
viral nucleic acids. MDA5 is one such sensor of virus presence and is activated by RNA …

Background The most common malignant tumor of the digestive system is HCC. However,
the mechanism and pathogenesis of HCC occurrence and progress are still unknown …

The diseases caused by viruses posed a great challenge to human health, the development
of which was driven by the imbalanced host immune response. Host innate immunity is an …

The innate immune system relies on a germ-line-encoded repertoire of pattern recognition
receptors (PRRs), activated by deeply conserved pathogen signatures, such as bacterial cell …