Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

Systemic sclerosis (SSc) is a multisystem connective tissue disorder featured by vascular
injury and fibrosis of the skin and various internal organs with autoimmune background …

Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients
with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in …

Objective. To assess the efficacy of rituximab (RTX) in SSc. Methods. Fourteen patients with
SSc were evaluated. Eight patients were randomized to receive two cycles of RTX at …

Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for
gastric cancer. This pathogen has also been considered a potential trigger of gastric …

SSc is an autoimmune disease characterized by inflammation and extracellular matrix
deposition that ultimately leads to loss of organ function. T cells appear to play a prominent …

In systemic sclerosis (SSc), a common and aetiologically mysterious form of scleroderma
(defined as pathological fibrosis of the skin), previously healthy adults acquire fibrosis of the …

Objective Breg cells, a regulatory cell subset that produces interleukin‐10 (IL‐10), play a
significant role in suppressing autoimmune responses and preventing autoimmunity. This …

A considerable amount of research time has been invested in studies aimed at elucidating
pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for …

Objectives: The safety and potential efficacy of rituximab was examined in diffuse cutaneous
systemic sclerosis (dc-SSc). Methods: A 24 week open-label study in which eight patients …