–Omic and electronic health record big data analytics for precision medicine

PY Wu, CW Cheng, CD Kaddi… - IEEE Transactions …, 2016 - ieeexplore.ieee.org
Objective: Rapid advances of high-throughput technologies and wide adoption of electronic
health records (EHRs) have led to fast accumulation of–omic and EHR data. These …

Epidemiology and causes of preterm birth

RL Goldenberg, JF Culhane, JD Iams, R Romero - The lancet, 2008 - thelancet.com
This paper is the first in a three-part series on preterm birth, which is the leading cause of
perinatal morbidity and mortality in developed countries. Infants are born preterm at less …

[PDF][PDF] 'Omic'technologies: genomics, transcriptomics, proteomics and metabolomics.

RP Horgan, LC Kenny - Obstetrician & Gynaecologist, 2011 - researchgate.net
'Omic'technologies adopt a holistic view of the molecules that make up a cell, tissue or
organism. They are aimed primarily at the universal detection of genes (genomics), mRNA …

Molecular mechanisms of hepatocellular carcinoma

RN Aravalli, CJ Steer, ENK Cressman - Hepatology, 2008 - journals.lww.com
Hepatocellular carcinoma (HCC) typically has poor prognosis, because it is often diagnosed
at an advanced stage. Heterogeneous phenotypic and genetic traits of affected individuals …

[HTML][HTML] Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques

R Romero, J Miranda, JP Kusanovic… - Journal of perinatal …, 2015 - degruyter.com
Introduction: The objectives of this study were: 1) to determine the amniotic fluid (AF)
microbiology of patients with the diagnosis of clinical chorioamnionitis at term using both …

Systems proteomics of liver mitochondria function

EG Williams, Y Wu, P Jha, S Dubuis, P Blattmann… - Science, 2016 - science.org
INTRODUCTION Over the past two decades, continuous improvements in “omics”
technologies have driven an ever-greater capacity to define the relationships between …

The prediction of early preeclampsia: Results from a longitudinal proteomics study

AL Tarca, R Romero, N Benshalom-Tirosh, NG Than… - PloS one, 2019 - journals.plos.org
Objectives To identify maternal plasma protein markers for early preeclampsia (delivery< 34
weeks of gestation) and to determine whether the prediction performance is affected by …

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

M Brown, WB Dunn, P Dobson, Y Patel, CL Winder… - Analyst, 2009 - pubs.rsc.org
The chemical identification of mass spectrometric signals in metabolomic applications is
important to provide conversion of analytical data to biological knowledge about metabolic …

Enabling individualized therapy through nanotechnology

JH Sakamoto, AL van de Ven, B Godin, E Blanco… - Pharmacological …, 2010 - Elsevier
Individualized medicine is the healthcare strategy that rebukes the idiomatic dogma of
'losing sight of the forest for the trees'. We are entering a new era of healthcare where it is no …

Developmental programming of early brain and behaviour development and mental health: a conceptual framework

BRH Van den Bergh - Developmental Medicine & Child …, 2011 - Wiley Online Library
The Developmental Origins of Health and Disease (DOHaD) hypothesis studies the short‐
and long‐term consequences of the conditions of the developmental environment for …