Objective Maternal diabetes in pregnancy is associated with structural anomalies of the fetal
heart, as well as hypertrophy and functional impairment. This systematic review and meta …

Gestational diabetes mellitus (GDM) and maternal obesity (MO) increase the risk of adverse
fetal outcomes, and the incidence of cardiovascular disease later in life. Extensive research …

Histone modifications are key epigenetic regulators that control chromatin structure and
gene transcription, thereby impacting on various important cellular phenotypes. Over the …

Globally, cardiovascular disease remains the leading cause of death. Most concerning is the
rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth …

Ischaemic heart disease (IHD) is a complex disorder and a leading cause of death and
morbidity in both men and women. Sex, however, affects several aspects of IHD, including …

Maternal diet modifies epigenetic programming in offspring, a potentially critical factor in the
immune dysregulation of modern societies. We previously found that prenatal fish oil …

The developmental origin of health and disease (DOHaD) hypothesis refers to the adverse
effects of suboptimal developmental environments during embryonic and early fetal stages …

There is an ever increasing prevalence of maternal obesity worldwide such that in many
populations over half of women enter pregnancy either overweight or obese. This review …

Infants born to diabetic or obese mothers are at greater risk of heart disease at birth and
throughout life, but prevention is hindered because underlying mechanisms remain poorly …

Offspring born to diabetic or obese mothers have a higher lifetime risk of heart disease.
Previously, we found that rat offspring exposed to late-gestational diabetes mellitus (LGDM) …