Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …

Receptors for immunoglobulins (Fc receptors) play a central role during an immune
response, as they mediate the specific recognition of antigens of almost infinite diversity by …

Nonsteroidal anti-inflammatory drug (NSAID)–induced urticarial and angioedema reactions
are among the most commonly encountered drug hypersensitivity reactions in clinical …

Asthma is the result of a complex interaction between environmental factors and genetic
variants that confer susceptibility. Studies of the genetics of asthma have previously been …

Immunoglobulin E (IgE) mediated immune responses seem to be directed against parasites
and neoplasms, but are best known for their involvement in allergies. The IgE network is …

Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis
edema, erythema, pruritus, or burning sensation). According to whether the natural course …

Non‐steroidal anti‐inflammatory drugs (NSAID s) are the medications most frequently
involved in hypersensitivity drug reactions. Because NSAID s are prescribed for many …

Background A subset of patients with chronic spontaneous urticaria (CSU) experience
disease exacerbations after receiving non‐steroidal anti‐inflammatory drugs (NSAID s). This …

Chronic urticaria (CU) is a common allergic skin disease that requires long-term
pharmacological treatment. Some patients with severe CU suffer a poor quality of life …

NSAIDs are the most important group of drugs involved in hypersensitivity drug reactions,
and include heterogeneous compounds with very different chemical structures. These …