The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics
to migrate to other locations and acquire new properties. Epithelial plasticity responses are …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

Colorectal cancers (CRCs) deficient in DNA mismatch repair (dMMR) contain abundant
CD8+ tumor-infiltrating lymphocytes (TILs) responding to the abundant neoantigens from …

The cell of origin and the development of breast cancer are not fully elucidated in BRCA1
mutation carriers, especially for estrogen receptor (ER)–positive breast cancers. Here, we …

The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes
with a high penetrance to several forms of epithelial malignancy. The large, nuclear …

Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic
resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor …

Background PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with
BRCA mutations, and their efficacy is even more limited in triple-negative breast cancer …

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

Element contamination, including that from heavy metals, is associated with gastrointestinal
tumorigenesis, but the effects and mechanisms of crucial element exposure associated with …