Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer

SA Jones, BJ Jenkins - Nature reviews immunology, 2018 - nature.com
The IL-6 family of cytokines consists of IL-6, IL-11, IL-27, IL-31, oncostatin M (OSM),
leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin 1 (CT-1) …

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease

SS Iyer, G Cheng - Critical Reviews™ in Immunology, 2012 - dl.begellhouse.com
ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

Systematic investigation of cytokine signaling activity at the tissue and single-cell levels

P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul… - Nature …, 2021 - nature.com
Cytokines are critical for intercellular communication in human health and disease, but the
investigation of cytokine signaling activity has remained challenging due to the short half …

The regulation of IL-10 production by immune cells

M Saraiva, A O'garra - Nature reviews immunology, 2010 - nature.com
Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

The immunobiology of interleukin-27

H Yoshida, CA Hunter - Annual review of immunology, 2015 - annualreviews.org
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …

LPS-induced cytokine production in human monocytes and macrophages

M Rossol, H Heine, U Meusch, D Quandt… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans

DS Shouval, J Ouahed, A Biswas, JA Goettel… - Advances in …, 2014 - Elsevier
Abstract Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit
proinflammatory responses of both innate and adaptive immune cells. An association …

The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

JG Bode, C Ehlting, D Häussinger - Cellular signalling, 2012 - Elsevier
In macrophages detection of gram-negative bacteria particularly involves binding of the
outer-wall component lipopolysaccharide (LPS) to its cognate receptor complex, comprising …

Cytokines in autoimmunity: role in induction, regulation, and treatment

KD Moudgil, D Choubey - Journal of Interferon & Cytokine …, 2011 - liebertpub.com
Cytokines play a pivotal role in the pathogenesis of autoimmune diseases. The precise
triggers for the breakdown of self-tolerance and the subsequent events leading to the …

[HTML][HTML] Type I IFN induces IL-10 production in an IL-27–independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in …

FW McNab, J Ewbank, A Howes… - The Journal of …, 2014 - journals.aai.org
Tuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently
causes∼ 1.4 million deaths per year, and it therefore remains a leading global health …