Chemokines are a family of small, secreted cytokines which regulate a variety of cell
functions. The CXC motif chemokine ligand 12 (CXCL12) binds to CXC chemokine receptor …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Increasing evidence indicates that the tumor microenvironment has critical roles in all
aspects of cancer biology, including growth, angiogenesis, metastasis and progression …

Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …

Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and
regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as …

Matrix metalloproteinases (MMPs) are a large family of zinc-endopeptidases which play
important roles in multiple physiological and pathological processes. These enzymes are …

Metastasis accounts for the vast majority of morbidity and mortality associated with
melanoma. Evidence suggests melanoma has a predilection for metastasis to particular …

Human endoglin is an RGD-containing transmembrane glycoprotein identified in vascular
endothelial cells. Although endoglin is essential for angiogenesis and its expression is up …

Aims/hypothesis Chemokine (CXC motif) ligand 12 (CXCL12)(also known as stromal cell-
derived factor-1 [SDF-1]-alpha) is a homeostatic chemokine with multiple roles in cell …

Chemokines and their receptors regulate the trafficking of leukocytes in hematopoiesis and
inflammation, and thus are fundamental to the immune integrity of the host. In parallel …