Genetic dissection of mammalian fertility pathways

MM Matzuk, DJ Lamb - Nature Medicine, 2002 - nature.com
The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

Fertilization: a sperm's journey to and interaction with the oocyte

M Ikawa, N Inoue, AM Benham… - The Journal of clinical …, 2010 - Am Soc Clin Investig
Mammalian fertilization comprises sperm migration through the female reproductive tract,
biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct …

A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets

N Schultz, FK Hamra… - Proceedings of the …, 2003 - National Acad Sciences
Understanding mammalian spermatozoan development and the events surrounding
fertilization has grown slowly, in part because of uncertainty about the number and identity of …

Mysteries and unsolved problems of mammalian fertilization and related topics

R Yanagimachi - Biology of reproduction, 2022 - academic.oup.com
Mammalian fertilization is a fascinating process that leads to the formation of a new
individual. Eggs and sperm are complex cells that must meet at the appropriate time and …

A profile of fertilization in mammals

PM Wassarman, L Jovine, ES Litscher - Nature cell biology, 2001 - nature.com
Fertilization is defined as the process of union of two gametes, eggs and sperm. When
mammalian eggs and sperm come into contact in the female oviduct, a series of steps is set …

The spermatozoon

EM Eddy, D O'brien - Knobil and Neill's physiology of …, 2006 - books.google.com
This chapter examines the novel structural features of the spermatozoon, their composition
and assembly, and the mechanisms regulating their function. The spermatozoon is a highly …

Magnetic micromotors for multiple motile sperm cells capture, transport, and enzymatic release

H Xu, M Medina‐Sánchez… - Angewandte Chemie …, 2020 - Wiley Online Library
An integrated system combining a magnetically‐driven micromotor and a synthetized protein‐
based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of …

Cell adhesion and fertilization: steps in oocyte transport, sperm-zona pellucida interactions, and sperm-egg fusion

P Talbot, BD Shur, DG Myles - Biology of reproduction, 2003 - academic.oup.com
Fertilization in mammals requires the successful completion of many steps, starting with the
transport of gametes in the reproductive tract and ending with sperm-egg membrane fusion …

Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of …

L Hermo, RM Pelletier, DG Cyr… - … research and technique, 2010 - Wiley Online Library
Spermiogenesis is a long process whereby haploid spermatids derived from the meiotic
divisions of spermatocytes undergo metamorphosis into spermatozoa. It is subdivided into …

[HTML][HTML] Real-time observation of acrosomal dispersal from mouse sperm using GFP as a marker protein

T Nakanishi, M Ikawa, S Yamada, M Parvinen, T Baba… - FEBS letters, 1999 - Elsevier
We produced transgenic mouse lines that accumulate mutated green fluorescent protein
(EGFP) in sperm acrosome, a membrane limited organelle overlying the nucleus. The sperm …