Anomalous development of brain structure and function in spina bifida myelomeningocele

J Juranek, MS Salman - Developmental disabilities research …, 2010 - Wiley Online Library
Spina bifida myelomeningocele (SBM) is a specific type of neural tube defect whereby the
open neural tube at the level of the spinal cord alters brain development during early stages …

A randomized trial of prenatal versus postnatal repair of myelomeningocele

NS Adzick, EA Thom, CY Spong… - … England Journal of …, 2011 - Mass Medical Soc
Background Prenatal repair of myelomeningocele, the most common form of spina bifida,
may result in better neurologic function than repair deferred until after delivery. We …

The Management of Myelomeningocele Study: full cohort 30-month pediatric outcomes

DL Farmer, EA Thom, JW Brock III, PK Burrows… - American journal of …, 2018 - Elsevier
Background Previous reports from the Management of Myelomeningocele Study
demonstrated that prenatal repair of myelomeningocele reduces hindbrain herniation and …

Children with spina bifida: key clinical issues

AD Sandler - Pediatric Clinics, 2010 - pediatric.theclinics.com
Spina bifida is the most common of the neural tube defects (NTDs), which include
myelomeningocele, encephalocele, and anencephaly. Spina bifida occulta is a common …

Salmonella infection drives promiscuous B cell activation followed by extrafollicular affinity maturation

R Di Niro, SJ Lee, JA Vander Heiden, RA Elsner… - Immunity, 2015 - cell.com
The B cell response to Salmonella typhimurium (STm) occurs massively at extrafollicular
sites, without notable germinal centers (GCs). Little is known in terms of its specificity. To …

Long-term neurofunctional outcome, executive functioning, and behavioral adaptive skills following fetal myelomeningocele surgery

E Danzer, NH Thomas, A Thomas, KB Friedman… - American Journal of …, 2016 - Elsevier
Background Myelomeningocele (MMC) represents the first nonlethal anomaly to be treated
by prenatal intervention. Case series and a prospective, randomized study show that fetal …

Fetal surgery for myelomeningocele is effective: a critical look at the whys

M Meuli, U Moehrlen - Pediatric surgery international, 2014 - Springer
Formerly, the disastrous cluster of neurologic deficits and associated neurogenic problems
in patients with myelomeningocele (MMC) was generally thought to solely result from the …

Optimizing health care for children with spina bifida

GS Liptak, A El Samra - Developmental disabilities research …, 2010 - Wiley Online Library
The health care needs of children with spina bifida are complex. They need specialists,
generalists, and an integrated system to deliver this complex care and to align and inform all …

Comparison of prenatal and postnatal treatments of spina bifida in Poland–a non-randomized, single-center study

J Zamłyński, A Olejek, T Koszutski… - The Journal of …, 2014 - Taylor & Francis
Objective: The aim of this study was a comparison of the outcomes of intrauterine
myelomeningocele (MMC) repairs (IUMR) in type II Chiari malformation (II CM) fetuses with …

Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications

E Danzer, L Joyeux, AW Flake… - … Medicine & Child …, 2020 - Wiley Online Library
Fetal myelomeningocele (fMMC) closure (spina bifida aperta) has become a care option for
patients that meet inclusion criteria, but it is clear that fetal intervention, while improving …