TAK1-TABs complex: a central signalosome in inflammatory responses
YR Xu, CQ Lei - Frontiers in Immunology, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
JNK signaling: regulation and functions based on complex protein-protein partnerships
A Zeke, M Misheva, A Reményi… - … and Molecular Biology …, 2016 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …
Cell type-specific function of TAK1 in innate immune signaling
AA Ajibade, HY Wang, RF Wang - Trends in immunology, 2013 - cell.com
Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …
The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
YX Ji, P Zhang, XJ Zhang, YC Zhao, KQ Deng… - Nature …, 2016 - nature.com
Tumour necrosis factor receptor-associated factor 6 (TRAF6) is a ubiquitin E3 ligase that
regulates important biological processes. However, the role of TRAF6 in cardiac hypertrophy …
regulates important biological processes. However, the role of TRAF6 in cardiac hypertrophy …
Post-translational modifications of the TAK1-TAB complex
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10
P Verheugd, AH Forst, L Milke, N Herzog… - Nature …, 2013 - nature.com
Adenosine diphosphate-ribosylation is a post-translational modification mediated by
intracellular and membrane-associated extracellular enzymes and many bacterial toxins …
intracellular and membrane-associated extracellular enzymes and many bacterial toxins …
Tripartite motif 8 (TRIM8) modulates TNFα-and IL-1β–triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination
Q Li, J Yan, AP Mao, C Li, Y Ran… - Proceedings of the …, 2011 - National Acad Sciences
The tripartite motif (TRIM)-containing proteins are a family of proteins that have been known
to be involved in divergent biological processes, including important roles in immune …
to be involved in divergent biological processes, including important roles in immune …
Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
PX Wang, XJ Zhang, P Luo, X Jiang, P Zhang… - Nature …, 2016 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance and a systemic pro-inflammatory response. Here we show that tumour necrosis …
resistance and a systemic pro-inflammatory response. Here we show that tumour necrosis …
USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation
Lys63-linked polyubiquitination of transforming growth factor-β-activated kinase 1 (TAK1)
has an important role in tumor necrosis factor-α (TNFα)-induced NF-κB activation. Using a …
has an important role in tumor necrosis factor-α (TNFα)-induced NF-κB activation. Using a …
TAK1 mediates convergence of cellular signals for death and survival
S Aashaq, A Batool, KI Andrabi - Apoptosis, 2019 - Springer
TGF-β activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been
implicated in regulating diverse range of cellular processes that include embryonic …
implicated in regulating diverse range of cellular processes that include embryonic …