The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation.
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities …

New guidelines for the management of chronic kidney disease have been developed by the
Canadian Society of Nephrology (Appendix 1 contains the fulltext guidelines; available at …

Background A significant proportion of donation after circulatory death (DCD) kidneys are
declined for transplantation because of concerns over their quality. Ex vivo normothermic …

Many factors influence the long‐term outcome of kidney transplantation, which is defined
very schematically by patient death or renal dysfunction leading to graft loss. The most …

Transplantable kidneys are in very limited supply. Accurate viability assessment prior to
transplantation could minimize organ discard. Rapid and accurate evaluation of intra …

Renal aging, by itself, is associated with alterations in renal morphology and a decline in
renal function, which is accelerated and/or accentuated by diseases such as diabetes …

Background. Delayed graft function is a frequent complication of kidney transplantation that
requires dialysis in the first week posttransplant. Materials and Methods. We searched for …

While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney
injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft …

BACKGROUND: During the past few years, there has been renewed interest in the use of
expanded criteria donors (ECD) for kidney transplantation to increase the numbers of …