Endogenous and exogenous regulation of redox homeostasis in retinal pigment epithelium cells: An updated antioxidant perspective

Y Markitantova, V Simirskii - International Journal of Molecular Sciences, 2023 - mdpi.com
The retinal pigment epithelium (RPE) performs a range of necessary functions within the
neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and …

Biomaterials used for tissue engineering of barrier-forming cell monolayers in the eye

S Sasseville, S Karami, A Tchatchouang… - … in Bioengineering and …, 2023 - frontiersin.org
Cell monolayers that form a barrier between two structures play an important role for the
maintenance of tissue functionality. In the anterior portion of the eye, the corneal …

Crocetin inhibits choroidal neovascularization in both in vitro and in vivo models

C Wang, X Li, J Su, J Duan, Y Yao, Q Shang - Experimental Eye Research, 2024 - Elsevier
Choroidal neovascularization (CNV) is the primary pathogenic process underlying wet age-
related macular degeneration, leading to severe vision loss. Despite current anti-vascular …

Extrinsic electric field modulates neuronal development and increases photoreceptor population in retinal organoids

DS Rajendran Nair, A Gupta, E Iseri, T Wei… - Frontiers in …, 2024 - frontiersin.org
Introduction Considering the significant role played by both intrinsic and extrinsic electric
fields in the growth and maturation of the central nervous system, the impact of short …

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice

PG Sreekumar, F Su, C Spee, E Hong, R Komirisetty… - Antioxidants, 2023 - mdpi.com
Although AMD is a complex disease, oxidative stress is a crucial contributor to its
development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 …

A Vicious NGF-p75NTR Positive Feedback Loop Exacerbates the Toxic Effects of Oxidative Damage in the Human Retinal Epithelial Cell Line ARPE-19

G Tringali, M Pizzoferrato, L Lisi, S Marinelli… - International Journal of …, 2023 - mdpi.com
In spite of its variety of biological activities, the clinical exploitation of human NGF (hNGF) is
currently limited to ocular pathologies. It is therefore interesting to test the effects of hNGF in …

Myelin regulatory factor (Myrf) is a critical early regulator of retinal pigment epithelial development

ML Brinkmeier, SQ Wang, H Pittman, LY Cheung… - bioRxiv, 2024 - biorxiv.org
Myelin regulatory factor (Myrf) is a critical transcription factor in early retinal and retinal
pigment epithelial development, and human variants in MYRF are a cause for …

[PDF][PDF] Advances in Cell-Based or Cell-Biomaterial Scaffolds for the Treatment of Age-Related Macular Degeneration

Z ming Li, Z Hu, Z Gao - 2025 - preprints.org
Age-related macular degeneration (AMD) is a degenerative retina disease characterized by
irreversible damage to macular cells and has become one of the leading causes of …

[PDF][PDF] Rapid developmental changes in retinal organoids after brief exposure to extrinsic electrical fields

B Thomas, DSR Nair, A Gupta, E Iseri, A Shehi, T Wei… - 2024 - scholar.archive.org
Considering the signi cant role played by both intrinsic and extrinsic electric elds in the
growth and maturation of the central nervous system, the impact of short exposure to …

Effects of insulin-like growth factor 1 on proliferation of different cell lines

OA Kachalova, T Moiseieva… - Biopolymers and …, 2024 - biopolymers.org.ua
Aim. Targeting cell proliferation may be an important therapeutic purpose in tumor growth,
tissue remodeling or degenerative diseases. Insulin-like growth factor IGF-1 is known as a …