The initiation of V (D) J recombination by the recombination activating gene 1 (RAG1) and
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …

▪ Abstract V (D) J recombination is the specialized DNA rearrangement used by cells of the
immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Nuclear processes such as transcription, DNA replication and recombination are
dynamically regulated by chromatin structure. Eukaryotic transcription is known to be …

Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …

Summary V (D) J recombination is initiated by the recombination activating gene (RAG)
proteins RAG-1 and RAG-2. The ability of antigen-receptor-gene segments to undergo V (D) …

Histone covalent modifications regulate many, if not all, DNA-templated processes, including
gene expression and DNA damage response. The biological consequences of histone …

The diversity of antigen receptors in the adaptive immune system of jawed vertebrates is
generated by a unique process of somatic gene rearrangement known as V (D) J …

Summary V (D) J recombination is the process by which antibody and T‐cell receptor
diversity is attained. During this process, antigen receptor gene segments are cleaved and …

Mutations of the recombinase activating genes (RAG) in humans underlie a broad spectrum
of clinical and immunological phenotypes that reflect different degrees of impairment of T …