Wound healing is highly specialized dynamic multiple phase process for the repair of
damaged/injured tissues through an intricate mechanism. Any failure in the normal wound …

Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of
different materials and adjustment of their physical and chemical properties, nanoparticles …

Non-healing wounds in Type 2 Diabetes (T2D) patients represent the most common cause
of amputation in the US, with an associated 5-year mortality of nearly 50%. Our lab has …

Diabetic wounds are one of the most challenging public health issues of the 21st century
due to their inadequate vascular supply, bacterial infections, high levels of oxidative stress …

Macrophages are essential immune cells and play a major role in the immune response as
pro-inflammatory or anti-inflammatory agents depending on their plasticity and functions …

The current treatments for wound healing still exhibit drawbacks due to limited availability at
the action sites, susceptibility to degradation, and immediate drug release, all of which are …

Diabetic foot ulcer (DFU) is a foremost cause of amputation in diabetic patients.
Consequences of DFU include infections, decline in limb function, hospitalization …

Highlights•Natural healing process is halted in inflammatory phase of chronic diabetic
wounds.•Increased angiogenesis and M2 macrophage content, with decreased ROS is …

Recently, the aging population has increased exponentially around the globe bringing more
challenges to improve quality of life in those populations while reducing the economic …

The α-gal epitope is a carbohydrate antigen which appeared early in mammalian evolution
and is synthesized in large amounts by the glycosylation enzyme α1, 3galactosyltransferase …