Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

Heparan sulfate proteoglycans (HSPGs) are components of the cell surface and
extracellular matrix, which bear long polysaccharides called heparan sulfate (HS) attached …

We hypothesized that bone evolved, in part, to enhance the ability of bony vertebrates to
escape danger in the wild. In support of this notion, we show here that a bone-derived signal …

Glycine is a major neurotransmitter involved in several fundamental neuronal processes.
The identity of the metabotropic receptor mediating slow neuromodulatory effects of glycine …

GPR158 is an orphan G protein–coupled receptor (GPCR) highly expressed in the brain,
where it controls synapse formation and function. GPR158 has also been implicated in …

GPR158, a class C orphan GPCR, functions in cognition, stress-induced mood control, and
synaptic development. Among class C GPCRs, GPR158 is unique as it lacks a Venus flytrap …

Many different intrinsically disordered proteins and proteins with intrinsically disordered
regions are associated with neurodegenerative diseases. These types of proteins including …

Precisely deciphering the molecular mechanisms of age-related memory loss is crucial to
create appropriate therapeutic interventions. We have previously shown that the histone …

Background and Purpose Members of the GPCR family are targeted by a significant fraction
of the available FDA‐approved drugs. However, the physiological role and pharmacological …

G-protein coupled receptors (GPCRs), one of the largest superfamilies of cell-surface
receptors, are heptahelical integral membrane proteins that play critical roles in virtually …