Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

The topic of this chapter, transient receptor potential ankyrin 1 (TRPA1), is a calcium-
permeable nonselective cation channel that is a member of the TRP family expressed on …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel
that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and …

Neuropathic pain is a chronic painful disease. Data have shown that reactive oxygen
species (ROS) are implicated in chronic pain. Particularly, the enhanced ROS production …

As alternatives to perfluorooctane sulfonate (PFOS) with shorter carbon chains or lower
proportion of fluorine atoms, perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate …

Chronic pain often predicts the onset of psychological distress. Symptoms including anxiety
and depression after pain chronification reportedly are caused by brain remodeling …

Background The underlying mechanisms of neuropathic pain remain unclear. This work
aimed to investigate the role of Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+ …