Evolution of contrast agents for ultrasound imaging and ultrasound-mediated drug delivery

V Paefgen, D Doleschel, F Kiessling - Frontiers in pharmacology, 2015 - frontiersin.org
Ultrasound (US) is one of the most frequently used diagnostic methods. It is a non-invasive,
comparably inexpensive imaging method with a broad spectrum of applications, which can …

Recent advances in molecular, multimodal and theranostic ultrasound imaging

F Kiessling, S Fokong, J Bzyl, W Lederle… - Advanced drug delivery …, 2014 - Elsevier
Ultrasound (US) imaging is an exquisite tool for the non-invasive and real-time diagnosis of
many different diseases. In this context, US contrast agents can improve lesion delineation …

PBCA-based polymeric microbubbles for molecular imaging and drug delivery

P Koczera, L Appold, Y Shi, M Liu, A Dasgupta… - Journal of controlled …, 2017 - Elsevier
Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. We
describe different types of targeted and drug-loaded poly (n-butyl cyanoacrylate)(PBCA) MB …

Functionalized polymer microbubbles as new molecular ultrasound contrast agent to target P-selectin in thrombus

B Li, R Aid-Launais, MN Labour, A Zenych, M Juenet… - Biomaterials, 2019 - Elsevier
Thrombotic diseases rarely cause symptoms until advanced stage and sudden death. Thus,
early detection of thrombus by a widely spread imaging modality can improve the prognosis …

Drug loading in poly (butyl cyanoacrylate)-based polymeric microbubbles

M Liu, A Dasgupta, P Koczera, S Schipper… - Molecular …, 2020 - ACS Publications
Microbubbles (MB) are routinely used ultrasound (US) contrast agents that have recently
attracted increasing attention as stimuli-responsive drug delivery systems. To better …

Functional micro/nanobubbles for ultrasound medicine and visualizable guidance

C Zhang, Y Li, X Ma, W He, C Liu, Z Liu - Science China Chemistry, 2021 - Springer
Chemically functionalized gas-filled bubbles with a versatile micro/nano-sized scale have
witnessed a long history of developments and emerging applications in disease diagnosis …

Ultrasound molecular imaging of E-selectin in tumor vessels using poly n-butyl cyanoacrylate microbubbles covalently coupled to a short targeting peptide

S Fokong, A Fragoso, A Rix, A Curaj, Z Wu… - Investigative …, 2013 - journals.lww.com
Objectives The purposes of this study were the development and preclinical evaluation of
clinically translatable E-selectin–specific ultrasound contrast agents based on a peptide …

Fluorescence labeled microbubbles for multimodal imaging

Å Barrefelt, Y Zhao, MK Larsson, G Egri… - Biochemical and …, 2015 - Elsevier
Air-filled polyvinyl alcohol microbubbles (PVA-MBs) were recently introduced as a contrast
agent for ultrasound imaging. In the present study, we explore the possibility of extending …

Multimodal micro, nano, and size conversion ultrasound agents for imaging and therapy

E Huynh, MA Rajora, G Zheng - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Ultrasound (US) is one of the most commonly used clinical imaging techniques. However,
the use of US and US‐based intravenous agents extends far beyond imaging. In particular …

Noninvasive molecular ultrasound monitoring of vessel healing after intravascular surgical procedures in a preclinical setup

A Curaj, Z Wu, S Fokong, EA Liehn… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Cardiovascular interventions induce damage to the vessel wall making
antithrombotic therapy inevitable until complete endothelial recovery. Without a method to …