Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Malaria is a major public health problem in the developing world owing to its high rates of
morbidity and mortality. Of all the malarial parasites that infect humans, Plasmodium …

Background Despite recent efforts and successes in reducing the malaria burden globally,
this infection still accounts for an estimated 212 million clinical cases, 2 million severe …

There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …

Severe malaria due to Plasmodium falciparum causes more than 800,000 deaths every
year. Primary therapy with quinine or artesunate is generally effective in controlling P …

Deferiprone is the only orally active iron-chelating drug to be used therapeutically in
conditions of transfusional iron overload. It is an orphan drug designed and developed …

Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage
of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a …

Introduction: Oxidative stress (caused by excess iron) can result in tissue damage, organ
failure and finally death, unless treated by iron chelators. The causative factor in the etiology …

Iron is essential for all human cells as well as neoplastic cells and invading microbes.
Natural and synthetic iron chelators could affect biological processes involving iron and …