ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

ImmunoPET: antibody-based PET imaging in solid tumors

R Manafi-Farid, B Ataeinia, S Ranjbar… - Frontiers in …, 2022 - frontiersin.org
Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

[HTML][HTML] ALKBH5 activates FAK signaling through m6A demethylation in ITGB1 mRNA and enhances tumor-associated lymphangiogenesis and lymph node …

R Sun, L Yuan, Y Jiang, Y Wan, X Ma, J Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Lymph node (LN) metastasis is common in patients with epithelial ovarian
cancer (EOC) and is associated with poor prognosis. Tumor-associated lymphangiogenesis …

ImmunoPET of ovarian and pancreatic cancer with AR9. 6, a novel MUC16-targeted therapeutic antibody

SK Sharma, KN Mack, A Piersigilli, J Pourat… - Clinical Cancer …, 2022 - AACR
Purpose: Advances in our understanding of the contribution of aberrant glycosylation to the
pro-oncogenic signaling and metastasis of tumor cells have reinvigorated the development …

[HTML][HTML] Site-specifically labeled 89Zr-DFO-trastuzumab improves immuno-reactivity and tumor uptake for immuno-PET in a subcutaneous HER2-positive xenograft …

LK Kristensen, C Christensen, MM Jensen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Antibody-based PET tracers are exceptionally well-suited for determination of the in vivo
biodistribution and quantification of therapeutic antibodies. The continued expansion in …

Non-invasive molecular imaging for precision diagnosis of metastatic lymph nodes: opportunities from preclinical to clinical applications

Z Cheng, J Ma, L Yin, L Yu, Z Yuan, B Zhang… - European Journal of …, 2023 - Springer
Lymph node metastasis is an indicator of the invasiveness and aggressiveness of cancer. It
is a vital prognostic factor in clinical staging of the disease and therapeutic decision-making …

The development and validation of a CT-based radiomics nomogram to preoperatively predict lymph node metastasis in high-grade serous ovarian cancer

H Chen, X Wang, F Zhao, X Chen, X Li, G Ning… - Frontiers in …, 2021 - frontiersin.org
Purpose To develop and validate a radiomics model for predicting preoperative lymph node
(LN) metastasis in high-grade serous ovarian cancer (HGSOC). Materials and Methods …

Ovarian cancer targeted theranostics

S Nimmagadda, MF Penet - Frontiers in oncology, 2020 - frontiersin.org
Ovarian cancer is a leading cause of death from gynecological malignancies. Although the
prognosis is quite favorable if detected at an early stage, the vast majority of cases are …

Visualizing galectin-3 binding protein expression with immunoPET

O Keinänen, SM Sarrett, S Delaney… - Molecular …, 2023 - ACS Publications
Galectin-3 binding protein (Gal-3BP) is a glycoprotein that is overexpressed and secreted by
several cancers and has been implicated as a marker of both tumor progression and poor …

Nuclear Medicine and Molecular Imaging Applications in Gynecologic Malignancies: A Comprehensive Review

T Khessib, P Jha, GA Davidzon, A Iagaru… - Seminars in Nuclear …, 2024 - Elsevier
Gynecologic malignancies, consisting of endometrial, cervical, ovarian, vulvar, and vaginal
cancers, pose significant diagnostic and management challenges due to their complex …