Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research
ZH Li, J Wang, JP Xu, J Wang, X Yang - Military Medical Research, 2023 - Springer
The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …
the fields of life science and medicine. In recent years, the clustered regularly interspaced …
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …
G Mancia, R Kreutz, M Brunström, M Burnier… - Journal of …, 2023 - journals.lww.com
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
[PDF][PDF] 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of …
M Brunström, M Burnier… - Journal of …, 2023 - docred-strapi-cms-prod.s3.sa-east-1 …
Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation
S Thériault, Z Li, E Abner, J Luan… - Nature …, 2024 - nature.com
There is currently no medical therapy to prevent calcific aortic valve stenosis (CAVS). Multi-
omics approaches could lead to the identification of novel molecular targets. Here, we …
omics approaches could lead to the identification of novel molecular targets. Here, we …
Phosphodiesterases in heart and vessels-From Physiology to Diseases
Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …
Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
C Szpirer - Journal of biomedical science, 2020 - Springer
The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
Mutant phosphodiesterase 3A protects from hypertension-induced cardiac damage
M Ercu, MB Mücke, T Pallien, L Markó, A Sholokh… - Circulation, 2022 - Am Heart Assoc
Background: Phosphodiesterase 3A (PDE3A) gain-of-function mutations cause
hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular …
hypertension with brachydactyly (HTNB) and lead to stroke. Increased peripheral vascular …
Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions
The endothelium is the innermost vascular lining performing significant roles all over the
human body while maintaining the blood pressure at physiological levels. Malfunction of …
human body while maintaining the blood pressure at physiological levels. Malfunction of …
Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy
G Subramaniam, K Schleicher, D Kovanich… - Circulation …, 2023 - Am Heart Assoc
Background: Signaling by cAMP is organized in multiple distinct subcellular nanodomains
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic …
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic …
PDE-mediated cyclic nucleotide compartmentation in vascular smooth muscle cells: from basic to a clinical perspective
Cardiovascular diseases are important causes of mortality and morbidity worldwide.
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …
Vascular smooth muscle cells (SMCs) are major components of blood vessels and are …