The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …

Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

The brain is often described as an" immune-privileged" organ due to the presence of the
blood-brain-barrier (BBB), which limits the entry of immune cells. In general, intracranial …

Parkinson's disease (PD) is currently the fastest growing disabling neurological disorder
worldwide, with motor and non-motor symptoms being its main clinical manifestations. The …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disease, with a progressive loss of dopaminergic cells and fibers. The purpose of this study …

The inability of damaged neurons to regenerate within the mature central nervous system
(CNS) is a significant neuroscientific challenge. Astrocytes are an essential component of …

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is
converted into an induced neuron without traversing a pluripotent state, has tremendous …

Parkinson's disease (PD) is a progressive neurodegenerative disease with a global burden
that affects more often in the elderly. The basal ganglia (BG) is believed to account for …

Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The
pathological hallmark of PD is loss of dopaminergic neurons and the presence of …

Recent insights into Parkinson's disease (PD), a progressive neurodegenerative disorder,
suggest a significant influence of the gut microbiome on its pathogenesis and progression …