Vascular anomalies (VA) are developmental anomalies of veins, arteries, lymphatics or
capillaries thought to be caused by mutations in genes that drive angiogenesis. Treatments …

Background Compassionate use is a system that provides patients with expedited access to
drugs which has not yet been approved, but currently in clinical trials. The investigational …

This was a prospective cohort study of eighteen patients with large and debilitating vascular
malformations with one or more major systemic complications. In all patients, we discovered …

Congenital vascular malformations (CVMs) are the result of an aberrant development during
embryogenesis. Although these lesions are present at birth, they are not always visible yet …

Objective The occurrence of unpredictable pain crises are the principal determinant of the
quality of life for patients with venous malformations (VM). A definite coagulation …

Background: The natural history of venous malformation (VM) and Klippel–Trenaunay
Syndrome (KTS) has not been quantitatively studied. To obtain benchmarks to guide …

Objective To evaluate the efficacy and safety of lauromacrogol foam sclerotherapy in the
treatment of children with lip venous malformation. Methods Fifty-two children (27 males and …

PIK3CA‐related overgrowth spectrum (PROS) encompasses different clinical entities
caused by somatic activating mutations in PIK3CA. Among PROS, CLOVES syndrome …

Vascular anomalies are caused by early defects in vascular development, secondary to
genetic variants in critical genes in angiogenesis or growth pathways. Typically, they present …