[HTML][HTML] PPARgamma in metabolism, immunity, and cancer: unified and diverse mechanisms of action
M Hernandez-Quiles, MF Broekema… - Frontiers in …, 2021 - frontiersin.org
The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …
is one of the most extensively studied ligand-inducible transcription factors. Since its …
Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale - Nature medicine, 2013 - nature.com
Adipose tissue, best known for its role in fat storage, can also suppress weight gain and
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …
metabolic disease through the action of specialized, heat-producing adipocytes. Brown …
Distinct but complementary contributions of PPAR isotypes to energy homeostasis
V Dubois, J Eeckhoute, P Lefebvre… - The Journal of clinical …, 2017 - Am Soc Clin Investig
Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …
PPARγ and the global map of adipogenesis and beyond
MI Lefterova, AK Haakonsson, MA Lazar… - Trends in Endocrinology …, 2014 - cell.com
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
(NR) superfamily of ligand-dependent transcription factors (TFs) and function as a master …
White, brown, beige/brite: different adipose cells for different functions?
M Giralt, F Villarroya - Endocrinology, 2013 - academic.oup.com
Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals.
Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent …
Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent …
Transcriptional and epigenetic control of brown and beige adipose cell fate and function
White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …
Osteogenesis depends on commissioning of a network of stem cell transcription factors that act as repressors of adipogenesis
Mesenchymal (stromal) stem cells (MSCs) constitute populations of mesodermal multipotent
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
cells involved in tissue regeneration and homeostasis in many different organs. Here we …
EBF2 determines and maintains brown adipocyte identity
The master transcription factor Pparγ regulates the general differentiation program of both
brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat …
brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat …
Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ
S Alex, K Lange, T Amolo, JS Grinstead… - … and cellular biology, 2013 - Am Soc Microbiol
Abstract Angiopoietin-like protein 4 (ANGPTL4/FIAF) has been proposed as a circulating
mediator between the gut microbiota and fat storage. Here, we show that transcription and …
mediator between the gut microbiota and fat storage. Here, we show that transcription and …
[HTML][HTML] Adipose tissue plasticity from WAT to BAT and in between
Adipose tissue plays an essential role in regulating energy balance through its metabolic,
cellular and endocrine functions. Adipose tissue has been historically classified into …
cellular and endocrine functions. Adipose tissue has been historically classified into …