Over the last six decades folded polymer chains—so‐called Single Chain Nanoparticles
(SCNPs)—have evolved from the mere concept of intramolecularly crosslinked polymer …

Polymers, with the capacity to tunably alter properties and response based on manipulation
of their chemical characteristics, are attractive components in biomaterials. Nevertheless …

Complex coacervates are a versatile platform to mimic the structure of living cells. In both
living systems and artificial cells, a macromolecularly crowded condensate phase has been …

Single-chain nanoparticles (SCNPs) are intriguing materials inspired by proteins that consist
of a single precursor polymer chain that has collapsed into a stable structure. In many …

Folding polymers into well-defined structures in solution is a critical step towards fully
synthetic protein mimics. Peptide motifs such as diphenylalanine (FF) provide a versatile …

Random heteropolymers (RHPs) consisting of three or more comonomers have been
routinely used to synthesize functional materials. While increasing the monomer variety …

The folding of proteins into functional nanoparticles with defined 3D structures has inspired
chemists to create simple synthetic systems mimicking protein properties. The folding of …

Statistical copolymers have been extensively used in chemical industries and our daily lives,
owing to their ease of synthesis and functionalization. However, self-assembly based on …

Protein–protein interactions (PPIs) are central to the cellular signaling and regulatory
networks that underlie many physiological and pathophysiological processes. It is …

Designing complex synthetic materials for enzyme immobilization could unlock the utility of
biocatalysis in extreme environments. Inspired by biology, we investigate the use of random …