Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …

Major depressive disorder (MDD) is a chronic relapsing psychiatric disorder. Conventional
antidepressants usually require several weeks of continuous administration to exert …

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually,
resulting in greater economic and social burdens. Moreover, the pathological mechanisms …

Abstract N-methyl-d-aspartate (NMDA) receptors are heterotetramers comprising two GluN1
and two alternate GluN2 (N2A-N2D) subunits. Here we report full-length cryo-EM structures …

N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …

Autoantibodies against neuronal membrane proteins can manifest in autoimmune
encephalitis, inducing seizures, cognitive dysfunction and psychosis. Anti-N-methyl-d …

N-methyl-d-aspartate receptors (NMDARs) belong to the ionotropic glutamate receptors
(iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal …

NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu)
targets in the central nervous system and are involved in synaptic plasticity, which is the …