Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by
autosomal dominant progressive myopathy, myotonia and multiorgan involvement. To date …

There are currently two clinically and molecularly defined forms of myotonic dystrophy:(1)
myotonic dystrophy type 1 (DM1), also known as 'Steinert's disease'; and (2) myotonic …

Myotonic dystrophy type 1 (DM1) is a multisystem disorder that affects skeletal and smooth
muscle as well as the eye, heart, endocrine system, and central nervous system. The clinical …

Molecular therapeutics for myotonic dystrophy will probably bridge the translational gap
between bench and bedside in the near future. There will still be a requirement for clinical …

Myotonic dystrophy type 1 (DM1) is caused by a CTG trinucleotide expansion in the 3′
untranslated region (3′ UTR) of DM protein kinase (DMPK). The key feature of DM1 …

Myotonic dystrophies are multisystemic diseases characterized not only by muscle and heart
dysfunction but also by CNS alteration. They are now recognized as brain diseases affecting …

Objectives: We evaluated the diagnostic contribution and the therapeutic and prognostic
implications of 3-dimensional electroanatomic mapping (EAM)-guided endomyocardial …

Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by
autosomal dominant progressive myopathy, myotonia and multiorgan involvement. To date …

The sinus node (SN) is located in the superior right atrium and is the natural pacemaker of
the human heart. 1 The electrical activity of the SN is under a precise regulation of the …

Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous
system, in part influenced by chronic inflammation. There is no proven effective therapy to …