[HTML][HTML] Genome regulation by polycomb and trithorax: 70 years and counting
B Schuettengruber, HM Bourbon, L Di Croce, G Cavalli - Cell, 2017 - cell.com
Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …
modifying factors originally identified as part of an epigenetic cellular memory system that …
[HTML][HTML] Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
JA Simon, RE Kingston - Molecular cell, 2013 - cell.com
Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
Capturing the onset of PRC2-mediated repressive domain formation
Summary Polycomb repressive complex 2 (PRC2) maintains gene silencing by catalyzing
methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a …
methylation of histone H3 at lysine 27 (H3K27me2/3) within chromatin. By designing a …
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide
Polycomb group (PcG) proteins are required for normal differentiation and development and
are frequently deregulated in cancer. PcG proteins are involved in gene silencing; however …
are frequently deregulated in cancer. PcG proteins are involved in gene silencing; however …
What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory
PA Steffen, L Ringrose - Nature reviews molecular cell biology, 2014 - nature.com
In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …
Epigenetic memory maintains gene expression states through cell generations without a …
Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
Abstract Polycomb Group (PcG) proteins organize chromatin at multiple scales to regulate
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …
gene expression. A conserved Sterile Alpha Motif (SAM) in the Polycomb Repressive …
Transcriptional silencing by polycomb-group proteins
U Grossniklaus, R Paro - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Polycomb-group (PcG) genes encode chromatin proteins involved in stable and heritable
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …
transcriptional silencing. PcG proteins participate in distinct multimeric complexes that …
Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma
A methionine substitution at lysine-27 on histone H3 variants (H3K27M) characterizes~ 80%
of diffuse intrinsic pontine gliomas (DIPG) and inhibits polycomb repressive complex 2 …
of diffuse intrinsic pontine gliomas (DIPG) and inhibits polycomb repressive complex 2 …
[HTML][HTML] TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
S Petruk, Y Sedkov, DM Johnston, JW Hodgson… - Cell, 2012 - cell.com
Propagation of gene-expression patterns through the cell cycle requires the existence of an
epigenetic mark that re-establishes the chromatin architecture of the parental cell in the …
epigenetic mark that re-establishes the chromatin architecture of the parental cell in the …
Histone modifications and mitosis: countermarks, landmarks, and bookmarks
F Wang, JMG Higgins - Trends in cell biology, 2013 - cell.com
The roles of post-translational histone modifications in regulating transcription and DNA
damage have been widely studied and discussed. Although mitotic histone marks …
damage have been widely studied and discussed. Although mitotic histone marks …