Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon - Trends in Microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be …

Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Next-generation probiotics: the spectrum from probiotics to live biotherapeutics

PW O'Toole, JR Marchesi, C Hill - Nature microbiology, 2017 - nature.com
The leading probiotics currently available to consumers are generally drawn from a narrow
range of organisms. Knowledge of the gut microbiota and its constituent actors is changing …

Gut microbiota and obesity

P Gérard - Cellular and molecular life sciences, 2016 - Springer
The human intestine harbors a complex bacterial community called the gut microbiota. This
microbiota is specific to each individual despite the existence of several bacterial species …

A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria

L Yao, GD D'Agostino, J Park, S Hang… - Nature …, 2022 - nature.com
Members of the human gut microbiome enzymatically process many bioactive molecules in
the gastrointestinal tract. Most gut bacterial modifications characterized so far are hydrolytic …

Metabolism of cholesterol and bile acids by the gut microbiota

P Gérard - Pathogens, 2013 - mdpi.com
The human gastro-intestinal tract hosts a complex and diverse microbial community, whose
collective genetic coding capacity vastly exceeds that of the human genome. As a …

Intestinal bacteria interplay with bile and cholesterol metabolism: implications on host physiology

N Molinero, L Ruiz, B Sánchez, A Margolles… - Frontiers in …, 2019 - frontiersin.org
Bile is a biological fluid synthesized in the liver, mainly constituted by bile acids and
cholesterol, which functions as a biological detergent that emulsifies and solubilizes lipids …

Factors influencing gallstone formation: a review of the literature

H Sun, J Warren, J Yip, Y Ji, S Hao, W Han, Y Ding - Biomolecules, 2022 - mdpi.com
Gallstone disease is a common pathology of the digestive system with nearly a 10–20%
incidence rate among adults. The mainstay of treatment is cholecystectomy, which is …

Microbial impact on cholesterol and bile acid metabolism: current status and future prospects

A Kriaa, M Bourgin, A Potiron, H Mkaouar… - Journal of lipid …, 2019 - ASBMB
Recently, the gut microbiota has emerged as a crucial factor that influences cholesterol
metabolism. Ever since, significant interest has been shown in investigating these host …

Germ‐free C57BL/6J mice are resistant to high‐fat‐diet‐induced insulin resistance and have altered cholesterol metabolism

S Rabot, M Membrez, A Bruneau, P Gérard… - The FASEB …, 2010 - Wiley Online Library
Recent studies showed that germ‐free (GF) mice are resistant to obesity when consuming a
high‐fat, high‐carbohydrate Western diet. However, it remains unclear what mechanisms …