Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Several families of protein kinases orchestrate the complex events that drive the cell cycle,
and their activity is frequently deregulated in hyperproliferative cancer cells. Although …

Many cancer cells display a CIN (C hromosome In stability) phenotype, by which they exhibit
high rates of chromosome loss or gain at each cell cycle. Over the years, a number of …

Simple Summary Lynch-like syndrome (LLS) is defined as colorectal cancer cases with
microsatellite instability (MSI) and loss of expression of MLH1, MSH2, MSH6, or PMS2 by …

Cells are open, highly ordered systems that are far away from equilibrium. For this reason,
the first function of any cell is to prevent the permanent threat of disintegration that is …

Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome
segregation and prevent aneuploidy, and severe mitotic spindle defects are typically …

The T asmanian D evil F acial T umour D isease (DFTD) provides a unique opportunity to
elucidate the long‐term effects of natural and anthropogenic selection on cancer evolution …

Advances in cancer treatment have led to an increase in patient survival. However,
exposure to genotoxic chemotherapeutic agents and ionizing radiation may induce …

This review discusses the topic of cell-cell fusion as it related to cancer causation,
progression and metastasis. The relevant time period is over a century of research and …

Hodgkin's lymphoma (HL) is a lymphoid malignancy representing 5% of all cancers in
children, 16% in adolescents, and 30–40% of all malignant lymphomas and has a survival …