The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

Therapeutic resistance and metastatic progression are responsible for the majority of cancer
mortalities. In particular, the development of resistance is a significant barrier to the efficacy …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is
often induced by DNA damage and other stress signals associated with growth arrest and …

Sex determination is a unique process that allows the study of multipotent progenitors and
their acquisition of sex-specific fates during differentiation of the gonad into a testis or an …

Sex-specific gonadal development starts with formation of the bipotential gonad, which then
differentiates into either a mature testis or an ovary. This process is dependent on activation …

The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …