Mass spectrometry-based metabolomics in microbiome investigations

A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …

Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular Plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity

JP Shaffer, LF Nothias, LR Thompson, JG Sanders… - Nature …, 2022 - nature.com
Despite advances in sequencing, lack of standardization makes comparisons across studies
challenging and hampers insights into the structure and function of microbial communities …

[HTML][HTML] A review of emerging micro-pollutants in hospital wastewater: environmental fate and remediation options

OJ Ajala, JO Tijani, RB Salau, AS Abdulkareem… - Results in …, 2022 - Elsevier
Hospitals played vital role in the maintenance and sustenance of human health. However,
hospital activities generate high volume of toxic solid and liquid containing diverse …

New software tools, databases, and resources in metabolomics: Updates from 2020

BB Misra - Metabolomics, 2021 - Springer
Background Precision medicine, space exploration, drug discovery to characterization of
dark chemical space of habitats and organisms, metabolomics takes a centre stage in …

Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches

MA Beniddir, KB Kang, G Genta-Jouve, F Huber… - Natural product …, 2021 - pubs.rsc.org
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …

Biosynthesis, evolution and ecology of microbial terpenoids

M Avalos, P Garbeva, L Vader, GP van Wezel… - Natural Product …, 2022 - pubs.rsc.org
Covering: through June 2021 Terpenoids are the largest class of natural products
recognised to date. While mostly known to humans as bioactive plant metabolites and part of …

Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Enhancing untargeted metabolomics using metadata-based source annotation

JM Gauglitz, KA West, W Bittremieux, CL Williams… - Nature …, 2022 - nature.com
Human untargeted metabolomics studies annotate only~ 10% of molecular features. We
introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry …

MS2DeepScore: a novel deep learning similarity measure to compare tandem mass spectra

F Huber, S van der Burg, JJJ van der Hooft… - Journal of …, 2021 - Springer
Mass spectrometry data is one of the key sources of information in many workflows in
medicine and across the life sciences. Mass fragmentation spectra are generally considered …