Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

Symptomatic acute hepatitis C occurs in only about 15% of patients who are infected with
hepatitis C virus (HCV). Acute hepatitis C is most often diagnosed in the setting of post …

Multiple inhibitory molecules create a profoundly immunuosuppressive environment during
chronic viral infections in humans and mice. Therefore, eliciting effective immunity in this …

Background Given the shortage of suitable donor hearts for cardiac transplantation, and the
favorable safety and efficacy of current agents used to treat hepatitis C virus (HCV), our …

Background & Aims: Broadly reactive neutralizing antibodies (nAbs) and multispecific T-cell
responses are generated during chronic hepatitis C virus (HCV) infection and yet fail to clear …

In most exposed individuals, hepatitis C virus (HCV) establishes a chronic infection; this long-
term infection in turn contributes to the development of liver diseases such as cirrhosis and …

Background & Aims: Human immunodeficiency virus (HIV)-1 infection has been associated
with enhanced microbial translocation, and microbial translocation is a mechanism through …

The hepatitis C virus (HCV) is a remarkably successful pathogen, establishing persistent
infection in more than two-thirds of those who contract it. Its success is related to its abilities …

Infections with hepatitis C virus (HCV) are marked by frequent viral persistence, chronic liver
disease, and extraordinary viral genetic diversity. Although much has been learned about …

Nearly 2.3 million individuals worldwide are coinfected with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV). Odds of HCV infection are six times higher in people living …