SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

P Hou, X Wang, H Wang, T Wang, Z Yu, C Xu, Y Zhao… - Autophagy, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

Science's Response to CoVID‐19

MJC Long, Y Aye - ChemMedChem, 2021 - Wiley Online Library
CoVID‐19 is a multi‐symptomatic disease which has made a global impact due to its ability
to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop …

Insight into the LFA-1/SARS-CoV-2 Orf7a complex by protein–protein docking, molecular dynamics, and MM-GBSA calculations

A Ongaro, E Oselladore, M Memo… - Journal of chemical …, 2021 - ACS Publications
In the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome, open
reading frames (ORFs) encode for viral accessory proteins. Among these, Orf7a structurally …

High prevalence of an alpha variant lineage with a premature stop codon in ORF7a in Iraq, winter 2020–2021

NAM Al-Rashedi, H Alburkat, AO Hadi, MG Munahi… - PLoS …, 2022 - journals.plos.org
Since the first reported case of coronavirus disease 2019 (COVID-19) in China, SARS-CoV-
2 has been spreading worldwide. Genomic surveillance of SARS-CoV-2 has had a critical …

[HTML][HTML] Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7b

T García-García, R Fernández-Rodríguez, N Redondo… - IScience, 2022 - cell.com
Summary SARS-CoV-2, the causative agent of the present COVID-19 pandemic, possesses
eleven accessory proteins encoded in its genome, and some have been implicated in …

A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs

VR Goud, R Chakraborty, A Chakraborty… - Computers in biology …, 2022 - Elsevier
The causative agent of the COVID-19 pandemic, the SARS-CoV-2 virus has yielded multiple
relevant mutations, many of which have branched into major variants. The Omicron variant …

[PDF][PDF] Dynamics of SARS-CoV-2 ORF7a Gene Deletions and Fate of Downstream ORF7b and ORF8 Genes Expression

AK Chakraborty - SunText Rev Biotechnol, 2022 - suntextreviews.org
SARS-CoV-2 small transactivator proteins like ORF7a, ORF7b and ORF8 were implicated as
modulator of cellular genes like STAT1/2, Tom70, IRF3 to down regulate IFNγ, IL6 and IgG …

Expediting the drug discovery for ideal leads against SARS-CoV-2 via molecular docking of repurposed drugs

A Sharma, M Kaur, P Yadav, G Singh… - Journal of Biomolecular …, 2023 - Taylor & Francis
Abstract SARS-CoV-2, the novel coronavirus spreading worldwide urges the need to
repurpose drugs that can quickly enter clinical trials to combat the on-going global …

Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins

OI Koifman, NS Lebedeva, YA Gubarev… - Chemistry of …, 2021 - Springer
Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins
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