Adipose tissue is a major source of energy for the human body. It is also a source of major
adipocytokines adiponectin and leptin. Insulin resistance is a condition in which insulin …

▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous
interest in the interaction between peripheral signals and brain targets involved in the …

TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a
neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary …

Adipose tissue plays a critical role in energy homeostasis, not only in storing triglycerides,
but also responding to nutrient, neural, and hormonal signals and secreting adipokines that …

The arcuate nucleus of the hypothalamus (ARH) is a critical component of forebrain
pathways that regulate a variety of neuroendocrine functions, including an important role in …

Over the past decade and a half it has become increasingly clear that adipose tissue is a
much more complex organ than was initially considered and that its metabolic functions …

The discovery of leptin in 1994 has led to astonishing advances in understanding the
regulation of energy balance in rodents and humans. The demonstration of leptin receptors …

Women have become increasingly physically active in recent decades. While exercise
provides substantial health benefits, intensive exercise is also associated with a unique set …

The discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent …

The homeostatic regulation of adiposity is a physiological concept that originated nearly 70
years ago, the genetic foundations of which have just begun to emerge. A key element of …