The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …

The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises
conserved heptad repeats, and post-translational modification of the CTD regulates …

Although chromatin organization and dynamics play a critical role in gene transcription, how
they interplay remains unclear. To approach this issue, we investigated genome-wide …

RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of
gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex …

The largest subunit of RNA polymerase II contains a C-terminal domain (CTD) that plays key
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Genes specifically expressed in neurons contain members with extended long introns.
Longer genes present a problem with respect to fulfilment of gene length transcription, and …

Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety
of physiological processes, including development of multiple diseases. In particular …