Pathogenesis of triple-negative breast cancer
F Derakhshan, JS Reis-Filho - Annual Review of Pathology …, 2022 - annualreviews.org
Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of
fundamentally different diseases with different histologic, genomic, and immunologic …
fundamentally different diseases with different histologic, genomic, and immunologic …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer
Combinatorial clinical trials of PARP inhibitors with immunotherapies are ongoing, yet the
immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we …
immunomodulatory effects of PARP inhibition have been incompletely studied. Here, we …
Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis
MD Wellenstein, SB Coffelt, DEM Duits… - Nature, 2019 - nature.com
Cancer-associated systemic inflammation is strongly linked to poor disease outcome in
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …
The shieldin complex mediates 53BP1-dependent DNA repair
SM Noordermeer, S Adam, D Setiaputra, M Barazas… - Nature, 2018 - nature.com
Abstract 53BP1 is a chromatin-binding protein that regulates the repair of DNA double-
strand breaks by suppressing the nucleolytic resection of DNA termini,. This function of …
strand breaks by suppressing the nucleolytic resection of DNA termini,. This function of …
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer
Despite objective responses to poly (ADP-ribose) polymerase (PARP) inhibition and
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
improvements in progression-free survival (PFS) compared to standard chemotherapy in …
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
[HTML][HTML] Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer
Interactions between stromal fibroblasts and cancer cells generate signals for cancer
progression, therapy resistance, and inflammatory responses. Although endogenous RNAs …
progression, therapy resistance, and inflammatory responses. Although endogenous RNAs …
The causes and consequences of genetic heterogeneity in cancer evolution
Recent studies have revealed extensive genetic diversity both between and within tumours.
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …
This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a …
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
Stromal communication with cancer cells can influence treatment response. We show that
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …