TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway.
Physiological cell death is important for maintaining homeostasis and optimal biological …

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies,
but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal …

Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that
governs the types of reactive oxygen species egressing from the organelle to affect cellular …

Cellular stress elicited by the toxic metal Cd 2+ does not coerce the cell into committing to
die from the onset. Rather, detoxification and adaptive processes are triggered concurrently …

Anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A), a calcium-activated chloride
channel (CaCC), is involved in many physiological functions such as fluid secretion, smooth …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important
therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality …

Cancer is a disease with marked heterogeneity in both response to therapy and survival.
Clinical and histopathological characteristics have long determined prognosis and therapy …