Colon targeted drug delivery systems have gained a great deal of attention as potential
carriers for the local treatment of colonic diseases with reduced systemic side effects and …

Colon-specific drug delivery systems (CDDS) are desirable for the treatment of a range of
local diseases such as ulcerative colitis, Crohn's disease, irritable bowel syndrome, chronic …

Fused deposition modeling (FDM) is a 3D printing technique based on the deposition of
successive layers of thermoplastic materials following their softening/melting. Such a …

The aim of the present work was to explore the feasibility of fused deposition modeling
(FDM) 3D printing in the manufacturing of capsular devices for oral pulsatile release based …

As per the WHO, colorectal cancer (CRC) caused around 935,173 deaths worldwide in 2020
in both sexes and at all ages. The available anticancer therapies including chemotherapy …

Aqueous-based film coating has become routine in the pharmaceutical industry. This
process eliminates the use of organic solvents and thus avoids economic, environmental …

The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core
surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able …

Introduction: Mini-tablets represent a new trend in solid dosage form design, with the main
goal of overcoming some therapeutic obstacles such as impaired swallowing and …

aminosalicylic acid (5-ASA) is the most widely used drug for the treatment of ulcerative
colitis. The benefits of targeted delivery of 5-ASA to the large intestine are well known …

Oral colon delivery is pursued through a number of formulation strategies with the aim of
enabling effective and well-tolerated treatments for large bowel pathologies or enhancing …