Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of
embryonic development and it is involved in homeostasis of adult tissues. In the …

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One
main pathological feature of COPD is the loss of functional alveolar tissue without adequate …

The vertebrate small intestine requires an enormous surface area to effectively absorb
nutrients from food. Morphological adaptations required to establish this extensive surface …

Cranial neural crest cells populate the future facial region and produce ectomesenchyme-
derived tissues, such as cartilage, bone, dermis, smooth muscle, adipocytes, and many …

Gastric cancer remains an important health challenge, accounting for a significant number of
cancer-related deaths worldwide. Therefore, a deeper understanding of the molecular …

Prickle is an evolutionarily conserved family of proteins exclusively associated with planar
cell polarity (PCP) signalling. This signalling pathway provides directional and positional …

Whereas aberrant activation of canonical Wnt/β-catenin signaling underlies the majority of
colorectal cancer cases, the contribution of non-canonical Wnt signaling is unclear. As …

Glypicans are proteoglycans that are bound to the outer surface of the plasma membrane by
a glycosylphosphatidylinositol anchor. The mammalian genome contains six members of the …

Background & Aims The embryonic small intestinal epithelium is highly proliferative, and
although much is known about mechanisms regulating proliferation in the adult intestine, the …