Advances in the treatment of mucoepidermoid carcinoma

S Sama, T Komiya, AK Guddati - World Journal of Oncology, 2021 - pmc.ncbi.nlm.nih.gov
Mucoepidermoid carcinoma (MEC) represents 10-15% of salivary neoplasms. Due to their
low incidence, it is challenging to conduct clinical trials and develop treatment guidelines …

Current state of knowledge on salivary gland cancers

HH Lin, KH Limesand, DK Ann - Critical Reviews™ in …, 2018 - dl.begellhouse.com
Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute
about 6% of head and neck cancer diagnoses based on estimate by American Head and …

Molecular targets in salivary gland cancers: a comprehensive genomic analysis of 118 mucoepidermoid carcinoma tumors

M Bou Zerdan, PA Kumar, D Zaccarini, J Ross… - Biomedicines, 2023 - mdpi.com
Introduction: Salivary gland carcinomas (SGC) are histologically diverse cancers and next-
generation sequencing (NGS) to identify key molecular targets is an important aspect in the …

Cephaeline is an inductor of histone H3 acetylation and inhibitor of mucoepidermoid carcinoma cancer stem cells

LC Silva, GB Borgato, VP Wagner… - Journal of Oral …, 2022 - Wiley Online Library
Aim To evaluate the potential use of Cephaeline as a therapeutic strategy to manage
mucoepidermoid carcinomas (MEC) of the salivary glands. Material and Methods UM‐HMC …

[HTML][HTML] Repurposing NFκB and HDAC inhibitors to individually target cancer stem cells and non-cancer stem cells from mucoepidermoid carcinomas

LC Silva, GB Borgato, VP Wagner… - American journal of …, 2023 - ncbi.nlm.nih.gov
Drug resistance remains a major obstacle in the treatment of mucoepidermoid carcinomas
(MEC) leading to tumor recurrence, disease progression, and metastasis. Emerging …

Clinical significance of histone deacetylase (HDAC)-1,-2,-4 and-6 expression in salivary gland tumors

D Pouloudi, M Manou, P Sarantis, N Tsoukalas… - Diagnostics, 2021 - mdpi.com
Salivary gland tumors (SGTs) comprise a group of rare neoplasms. Locally aggressive,
recurrent and/or metastatic SGTs are notorious for their resistance to systemic therapy …

Targeting of CD133+ cancer stem cells by mesenchymal stem cell expressing TRAIL reveals a prospective role of apoptotic gene regulation in non-small cell lung …

K Shaik Fakiruddin, MN Lim, N Nordin, R Rosli… - Cancers, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are emerging as vehicles for anti-tumor cytotherapy;
however, investigation on its efficacy to target a specific cancer stem cell (CSC) population …

Distinct histone H3 modification profiles correlate with aggressive characteristics of salivary gland neoplasms

A Lam-Ubol, E Phattarataratip - Scientific Reports, 2022 - nature.com
Post-translational modification of histones is the crucial event that affect many tumor-specific
traits. A diverse type of histone modifications had been reported in different cancers with …

Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma

K Parag-Sharma, J Tasoulas, AM Musicant… - Oral oncology, 2021 - Elsevier
Objectives Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland
malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to …

Up‐regulation of TNF‐alpha/NFkB/SIRT1 axis drives aggressiveness and cancer stem cells accumulation in chemoresistant oral squamous cell carcinoma

LR de Castro, LD de Oliveira, TM Milan… - Journal of Cellular …, 2024 - Wiley Online Library
Tumor resistance remains an obstacle to successfully treating oral squamous cell carcinoma
(OSCC). Cisplatin is widely used as a cytotoxic drug to treat solid tumors, including …