Although an immense knowledge has accumulated concerning regulation of cholesterol
homeostasis in the body, this does not include the brain, where details are just emerging …

Cryptochromes are blue, ultraviolet-A photoreceptors. They were first characterized for
Arabidopsis and are also found in ferns and algae; they appear to be ubiquitous in the plant …

The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that
are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate …

We demonstrate that mice lacking the oxysterol receptor, LXRα, lose their ability to respond
normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in …

Accumulation of cholesterol causes both repression of genes controlling cholesterol
biosynthesis and cellular uptake and induction of cholesterol 7α-hydroxylase, which leads to …

Oxygenated derivatives of cholesterol (oxysterols) present a remarkably diverse profile of
biological activities, including effects on sphingolipid metabolism, platelet aggregation …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

▪ Abstract Cholesterol balance is maintained by a series of regulatory pathways that control
the acquisition of cholesterol from endogenous and exogenous sources and the elimination …

Tangier disease, a condition characterized by low levels of high density lipoprotein and
cholesterol accumulation in macrophages, is caused by mutations in the ATP-binding …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …