Dimerization is a promising strategy to develop novel drug candidates that could extend the
biological spectrum, enhance the activity, overcome drug resistance, as well as improve …

Infections especially tuberculosis caused by various bacteria including mycobacteria result
in millions of lives every year, but the control of bacterial infections is challenged by the …

The rapid emergence of drug-resistant strains and novel viruses have motivated the search
for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as …

Parasites are responsible for the most neglected tropical diseases, affecting over a billion
people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible …

Background Oils in traditional medicine are important products and used routinely for
therapeutic purposes. Rose oil (Rosa damascene Mill), a product of Persian medicine, is …

Trichomonas vaginalis is responsible for the most common non-viral, sexually transmitted
infection, human trichomoniasis, and is associated with an increased susceptibility to HIV …

Indazole is an important scaffold in medicinal chemistry. At present, the progress on
synthetic methodologies has allowed the preparation of several new indazole derivatives …

Background Trichomonas tenax may appear in the oral cavity of humans due to poor
dentition or oral hygiene. Pyopneumothorax is a serious complication of lower respiratory …

The nitroimidazole derivatives have an active broad spectrum, being toxic to anaerobic
bacteria and protozoa. Nimorazole (NMZ) belongs to this group of drugs, and its proposed …

We prepared a series of 10 carbamates derivatives based on two common antiprotozoal
drugs: metronidazole (1–5) and secnidazole (6–10). The compounds were tested in vitro …