Highlights•Spatial metabolomics technology has made great advancements in recent
years.•Metabolic molecular histology is a powerful tool to reveal cellular states.•Dynamic …

The metabolic demands of neuronal activity are both temporally and spatially dynamic, and
neurons are particularly sensitive to disruptions in fuel and oxygen supply. Glucose is …

Schizophrenia is a chronic, neurodevelopmental disorder with unknown aetiology and
pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities …

Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of
familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that …

Abstract Objective Glucose-1, 6-bisphosphate (G-1, 6-BP), a byproduct of glycolysis that is
synthesized by phosphoglucomutase 2 like 1 (PGM2L1), is particularly abundant in neurons …

The tumor microenvironment is a determinant of cancer progression and therapeutic
efficacy, with nutrient availability playing an important role. Although it is established that the …

Purpose: Glutamatergic neuron–glioma synaptogenesis and peritumoral hyperexcitability
promote glioma growth in a positive feedback loop. The objective of this study was to …

Stable isotope-resolved metabolomics comprises a critical set of technologies that can be
applied to a wide variety of systems, from isolated cells to whole organisms, to define …

Mass spectrometry imaging (MSI) allows for label-free spatial molecular interrogation of
tissues. With advances in the field over recent years, the spatial resolution at which MSI data …

Immunometabolism is a rapidly developing field that holds great promise for diagnostic and
therapeutic benefits to human diseases. The field has emerged based on seminal findings …