Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

In this volume of the IJE, Gao and colleagues explore the causal effect of adiposity on
several cancers using twosample Mendelian randomization (MR), and find some evidence …

Objective To evaluate whether body size in early life has an independent effect on risk of
disease in later life or whether its influence is mediated by body size in adulthood. Design …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Background The early life environment experienced by an individual in utero and during the
neonatal period is a major factor in shaping later life disease risk-including susceptibility to …

A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis …

The past decade has been proclaimed as a hugely successful era of gene discovery through
the high yields of many genome-wide association studies (GWAS). However, much of the …

Background: Both genetic and environmental factors are known to affect body mass index
(BMI), but detailed understanding of how their effects differ during childhood and …

Over the last three decades, the prevalence of obesity has increased rapidly in populations
around the world. Despite a wealth of research, the relative contributions of the different …

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin–
melanocortin pathway in controlling energy balance, appetite and body weight. The majority …