Biomaterials and advanced technologies for hemostatic management of bleeding
DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …
associated, or drug‐induced blood disorders can cause significant morbidities and …
Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
Genetically engineered transfusable platelets using mRNA lipid nanoparticles
Platelet transfusions are essential for managing bleeding and hemostatic dysfunction and
could be expanded as a cell therapy due to the multifunctional role of platelets in various …
could be expanded as a cell therapy due to the multifunctional role of platelets in various …
The use of low‐titer group O whole blood is independently associated with improved survival compared to component therapy in adults with severe traumatic …
BACKGROUND There is a resurgence in the use of low‐titer group O whole blood (LTOWB)
for hemorrhagic shock. We hypothesized the use of LTOWB compared to component …
for hemorrhagic shock. We hypothesized the use of LTOWB compared to component …
Whole blood for hemostatic resuscitation of major bleeding
Recent combat experience reignited interest in transfusing whole blood (WB) for patients
with life‐threatening bleeding. US Army data indicate that WB transfusion is associated with …
with life‐threatening bleeding. US Army data indicate that WB transfusion is associated with …
Refrigeration and cryopreservation of platelets differentially affect platelet metabolism and function: a comparison with conventional platelet storage conditions
L Johnson, S Tan, B Wood, A Davis, DC Marks - Transfusion, 2016 - Wiley Online Library
BACKGROUND Alternatives to room temperature storage of platelets (PLTs) may be
beneficial to extend the limited shelf life and support transfusion logistics in rural and military …
beneficial to extend the limited shelf life and support transfusion logistics in rural and military …
Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma
METHODS We analyzed the (2015–2016) Trauma Quality Improvement Program. We
included adult (age,≥ 18 years) trauma patients presenting with hemorrhagic shock and …
included adult (age,≥ 18 years) trauma patients presenting with hemorrhagic shock and …
[HTML][HTML] Platelet‐inspired nanomedicine in hemostasis thrombosis and thromboinflammation
Platelets are anucleate cell‐fragments derived predominantly from megakaryocytes in the
bone marrow and released in the blood circulation, with a normal count of 150 000–40 000 …
bone marrow and released in the blood circulation, with a normal count of 150 000–40 000 …
Storage of platelets at 4 C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses
BACKGROUND Platelet (PLT) storage has been limited to 5 days at room temperature due
to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT …
to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT …
Damage control resuscitation
Damage control resuscitation (DCR) is a strategy for resuscitating patients from hemorrhagic
shock to rapidly restore homeostasis. Efforts are focused on blood product transfusion with …
shock to rapidly restore homeostasis. Efforts are focused on blood product transfusion with …