The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic
studies, has advanced our understanding of the evolutionary forces that shape cancer …

During the course of tumorigenesis and subsequent metastasis, malignant cells gradually
diversify and become more heterogeneous. Consequently, the tumor mass might be …

Covering the major topics of evolutionary game theory, Game-Theoretical Models in Biology,
Second Edition presents both abstract and practical mathematical models of real biological …

Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically
relevant clonal dynamics remain limited. We investigated spatial and temporal features of …

Background Adaptive therapy aims to tackle cancer drug resistance by leveraging resource
competition between drug-sensitive and resistant cells. Here, we present a theoretical study …

Characterizing the mode—the way, manner or pattern—of evolution in tumours is important
for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred …

In scientific context, the first step for scientific theoretical and methodological production is
the epistemological analysis. What are assumptions for interaction between oncology and …

Explaining the emergence and maintenance of intratumor heterogeneity is an important
question in cancer biology. Tumor cells can generate considerable subclonal diversity …

Genome instability of cancer cells translates into increased entropy and lower information
processing capacity, leading to metabolic reprograming toward higher energy states …

Microsatellite unstable colorectal cancer (MSI-CRC) can arise through germline mutations in
mismatch repair (MMR) genes in individuals with Lynch syndrome (LS), or sporadically …