Introduction This meta-analysis aimed to characterize the nature and magnitude of amyloid
(Aβ)-related cognitive impairment and decline in cognitively normal (CN) older individuals …

Subjective cognitive decline (SCD), characterized by a very early and subtle cognitive
decline prior to the appearance of objective cognitive impairment, is considered to be the …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) measures abilities broadly
related to executive function (EF), including WAIS-R Digit Symbol Substitution, Digit Span …

Objective: We assessed whether preclinical Alzheimer disease (AD) based on CSF
biomarkers at baseline predicts decline in cognitive functioning as measured by repeated …

Importance Presently, the clinical standard for reporting the results of an amyloid positron
emission tomography scan is to assign a dichotomous rating of positive or negative for the …

The concept of cognitive reserve (CR) originated from discrepancies between the degree of
brain pathology and the severity of clinical manifestations. CR has been characterized …

Neurodegeneration due to Alzheimer's disease (AD) can progress over decades before
dementia becomes apparent. Indeed, patients with mild cognitive impairment (MCI) already …

Beta-amyloid (Aβ) is a histopathological hallmark of Alzheimer's disease dementia, but high
levels of Aβ in the brain can also be found in a substantial proportion of nondemented …

Background Research suggests that cerebral small vessel disease (CSVD), amyloid, and
pTau contribute to age-related cognitive decline. It remains unknown how these factors …

Background In the field of Alzheimer's disease (AD), the validation of biomarkers for early
AD diagnosis and for use as a surrogate outcome in AD clinical trials is of considerable …